Saturday, 13th February 33rd Lorne Cancer Conference 2021

• Stem Cells and Cancer – New Horizons - Connie Eaves
• T-ALL can evolve to oncogene independence - Matthew P McCormack
• To be provided - Elaine Fuchs

• Functional genomics identifies therapeutic dependencies in diffuse intrinsic pontine glioma - Sarah Parackal
• Design of a low-cost random positioning machine (rpm) for head and neck cancer research - Marcus ME Eymael
• Escaping the endoplasmic reticulum: endoplasmic reticulum chaperones at the cell surface in glioblastoma - Alexis Minchaca
• Acquired mutations within the JAK2 kinase domain confer resistance to JAK inhibitors in in vitro models of acute lymphoblastic leukaemia driven by high-risk JAK2 fusion genes - Charlotte EJ Downes
• Symptomatology of colorectal cancer and polyps: A prospective cohort study - Benjamin Julien
• Clinical implications of hook-related protein expression in hormone-receptor positive breast cancer - Emma-Anne Karlsen
• Acquired PARP inhibitor resistance via RAD51C promoter methylation loss in high grade serous ovarian carcinoma - Ksenija Nesic
• PPARα and PPARγ are associated with pleural mesothelioma growth, but therapeutic inhibition is ineffective in preclinical models   - Lizeth Orozco Morales
• A novel orthotopic patient-derived xenograft model of radiation-induced glioma following medulloblastoma - Jacqueline P. Whitehouse
• Developing clinically relevant fractionated radiotherapy protocols in mouse models of medulloblastoma - Jessica Buck
• Interleukin 11 signalling promotes glioblastoma progression - Sarah Stuart
• The impact of miR-21 on miRNA expression in head and neck cancer - Meredith Hill
• The dual action of miR-21 and miR-499 on the regulation of programmed cell death 4 (PDCD4) - Meredith Hill
• Novel qPCR Multiplex Approach to detect E6/E7 mRNA in HPV Positive Head and Neck Cancer - Fiona T Deutsch
• Using a viral interactome to uncover mechanistic links between HPV16 and specific microRNAs in head and neck cancers - Dayna Mason
• Histone deacetylase inhibitors (HDACi) as potential differentiation therapy in lung adenocarcinoma - Wai Chin Chong
• A novel Src-FRET biosensor mouse providing real-time insights into the dynamic spatiotemporal regulation of Src activity during cancer progression, invasion and metastasis - David Herrmann
• Unbiased whole-genome gain-of-function CRISPRa screening to define the mechanisms of platinum-resistance in small cell lung cancer - Quinton Luong
• Therapeutic targeting of ubiquitin-specific protease 5 in MYCN-driven neuroblastoma - Ane Kleynhans
• Targeting the extracellular matrix in mammary tumour progression - Michael Papanicolaou
• Role of the multi-drug resistance efflux pump MDR1 in conferring resistance to the BH3- mimetic compounds - Farima Moghaddaskho
• Modelling chemotherapy-induced apoptosis to improve response in high-risk neuroblastoma - Jeremy Han
• The pleiotropic role of JNK in ER+ breast cancer - Yolande EI O'Donnell
• Disruption of CDK11 in the POLII transcription cycle as a novel therapeutic approach for acute myeloid leukaemia - Jennifer R Devlin
• Identifying factors which confer resistance to BH3-mimetic drugs targeting MCL-1 in MYC-driven lymphomas - Sarah T Diepstraten
• Implementation of precision oncology in breast cancer care in Qld (Q-IMPROvE). - Amy McCart Reed
• Investigating the role of mutant TRP53 in the development and sustained growth of tumours - Elizabeth Lieschke
• Novel High Affinity EGFRvIII CAR T Cells Effectively Eliminate Glioblastoma   - Rebecca C Abbott
• Investigating the factors involved in TP53 mediated tumour suppression - Elizabeth Lieschke
• Modulating expression of the pro-apoptotic BH3-only protein, NOXA - Zhuo-Fan Xu
• Drug responsiveness profiling of patient-derived metastatic cutaneous squamous cell carcinoma - Benjamin Genenger
• CD5 Negativity as a prognostic indicator in Mantle cell lymphoma - AMAR RANJAN SINGH
• Bioinformatics analyses to uncover the molecular mechanism underlying T cell exhaustion caused by chronic infection - Yang Liao
• Wrongly identified nucleotide sequence reagents within the gene-focussed cancer research literature - Jennifer A Byrne
• Epithelial versus stromal targeting of FAK in pancreatic cancer: deconstructing treatment regimens according to personal tumour status for improved outcome in personalised medicine - Kendelle J Murphy
• Novel diagnostic and prognostic biomarkers in prostate cancer - Jessica Da Gama Duarte
• Splicing Hotspots, possible targets for universal cancer vaccination immunotherapy - Pouya Faridi
• Transmissible Endoplasmic Reticulum Stress (TERS) Between Pancreatic Cancer and Pancreatic Stellate Cells Alters Cancer Proliferation, Chemoresistance and Migration.  - Georgia M Porter
• Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression   - Kelvin Yip
• Development of novel autophagy inhibitors based anti-cancer combination therapy - Yomna Saleh
• Fit for repurpose: itraconazole as a novel treatment approach for pancreatic cancer - Sean Porazinski
• Targeting BCL-2 family proteins in combination with aberrant BRAF signalling pathway inhibitors for treatment of melanoma - Lahiru Gangoda
• Differential kynurenine pathway metabolism in highly-metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression - Benjamin Heng
• BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage - Kerstin Brinkmann
• Drugs targeting colorectal cancer stem cells - Reem ALHulais
• Secretory profiling identifies guggulsterone mediated down-regulation of VEGF, IL6 and MMP9 in breast cancer cells - Anjana Anand
•  Improved BRAF/MEK inhibitors efficacy using a high-fat diet in mice - shaghayegh Arabi
• Identifying effective combinations of targeted therapies, using novel pre-clinical models, to improve treatment options for high-grade serous endometrial cancer - Holly E Barker
• Nucleic acid aptamers as diagnostic probes for the detection of cancer stem cells and isolation of circulating tumour cells - Michelle L Bauer
• MLL1-induced Wnt/β-catenin activity promotes colon tumorigenesis - Jia Bian
• Leiomyoma of the male nipple - Liam Bibo
• Rapid determination of cytokine release from T cells with no-transfer, no-wash Lumit™ immunoassays - David Boucher
• Comparing the immuno-genomic landscape of high grade serous ovarian carcinoma patients in the SOLACE2 clinical trial - Nirashaa Bound
• ASSESSMENT OF THE IMMUNE MICROENVIRONMENT IN OESOPHAGEAL CANCER REVEALS A POTENTIAL PROGNOSTIC ROLE FOR TUMOUR INFILTRATING NEUTROPHILS - Carlos S Cabalag
• Generation and validation of C57BL/6 syngeneic pancreatic cancer-associated fibroblasts as a new tool to study stromal and immune interactions in pancreatic cancer - Cecilia Chambers
• LOX family inhibition improves response to standard of care therapy in desmoplastic pancreatic cancer - Jessica L Chitty
• A unique cohort of uterine leiomyosarcoma in the WEHI-Stafford Fox Rare Cancer Program - Genevieve Dall
• IRF2BP2 is a new estrogen receptor co-factor in breast cancer - Amy R. Dwyer
• MYC antagonist MNT: A new target for acute myeloid leukaemia - Karla Charlotte Fischer
• Screening and identification of therapeutic modulators of type I IFN signaling in bone metastatic breast cancer cell lines - Miriam Fuentes
• Targeting two new regulators of TRAIL signalling and cancer cell survival - Anna Gabrielyan
• Systems modelling and characterization of TGFβ-Hippo signalling crosstalk reveals ITCH promotes breast tumorigenesis through modulation of opposing YAP protein complexes - Milad Ghomlaghi
• IFNγ modulates the immunopeptidome of triple negative breast cancer cells by enhancing and diversifying antigen processing and presentation - Gabriel Goncalves
• Chromosomal instability in cancer triggers metabolic changes - Stephen L Gregory
• Investigating the dynamic and heterogeneous nature of drug resistance in ER+ breast cancer using mathematical modelling. - Anthony Hart
• Whole genome and exome sequencing of a rare ovarian carcinosarcoma identify tumour neoantigens that are targetable with CD8+ T cytotoxic cells. - Gwo Yaw Ho
• AR interacts with GATA3 to induce a luminal epithelial phenotype in breast cancer through regulation of lineage-restricted genes - Leila Hosseinzadeh
• Understanding and overcoming resistance to ribosome targeting therapy in human haematological malignancies - Xinran Huang
• Interrogating the cell-of-origin of BRCA1 mutant ovarian cancer to inform targeted strategies for cancer prevention - Rachel Joyce
• Characterisation of immune cell subsets of tumour infiltrating lymphocytes in brain metastases - Priyakshi Kalita-de Croft
• Benign mucin‐containing pancreatic lymphoepithelial cyst manifesting as a mucinous neoplasm - Charbel Karam
• Optimisation of 3D vasculature imaging to characterise the cellular features of breast cancer metastases - Sabrina M Lewis
• Inhibiting PRMT5: A novel therapeutic strategy for MAPK inhibitor-resistant melanoma  - Lydia Lim
• Improving success rate of Whole Genome Sequencing in rare gynaecological cancers - Ratana Lim
• Sequential PET imaging of PD-L1 in non-small cell lung cancer during chemoradation using ⁸⁹Zr-durvalumab: The ImmunoPET trial - Michael MacManus
• Expression and role of LIN28B in medulloblastoma - Ahmed Maklad
• Dissecting cellular targeting biases of adeno- and lenti-viruses in the adult mouse lung - Jackson McDonald
• Porcupine inhibition as a strategy for personalized treatment in pancreatic cancer - Benjamin McLean
• Complexity of OCT4 gene expression in stem cells and its implication in cancers - Majid Mehravar
• Modulating mRNA translation machinery to enhance chemotherapy response in triple-negative breast cancer - Heloisa Helena Milioli
• Overcoming resistance to immunotherapy with BH3 mimetics - ZIZHEN MING
• Pharmacological inhibition of pro-survival BCL-2 proteins with BH3-mimetics in glioblastoma multiforme (GBM) - Diane Moujalled
• Novel subtype-specific mutations in small cell lung cancer - Jin Ng
• Role of fibroblasts in mammary gland development and breast cancer - Rosa Pascual
• Impact of protein arginine methyltransferase (PRMT5) inhibition on the melanoma immune microenvironment - Riyaben P Patel
• Investigating the role of Histone Acetyl Transferases in T-cell mediated tumour-immune responses - Lizzy Pijpers
• Whole genome in vivo CRISPR/Cas9 screen identifies novel tumor suppressor genes in Eμ-Myc lymphoma - Margaret A Potts
• Role of SULF1 in triple-negative breast cancer progression and metastasis - Laura Rangel
• Understanding the pre-metastatic niche formation of triple-negative breast cancer at single-cell resolution - Laura Rodriguez de la Fuente
• Small Bowel Adenocarcinoma: Revisited - Muhammad Farqhan Rosley
• Epigenome erosion and neural crest-like phenotypic reprogramming in triple-negative breast cancer - Jodi M Saunus
• Precision oncology in rare gynaecological cancers using the WEHI-Stafford Fox Rare Cancer Program. - Clare L Scott
• Inhibition of T-type calcium channels suppresses cell proliferation and invasion and promotes apoptosis in human medulloblastoma cell lines - Mohammed Sedeeq
• High throughput drug screen in EBV-associated T/NK cell lymphoma cells identifies potent HDAC inhibitors that synergise with BH3-mimetics. - Nenad Sejic
• Autoantibodies as prognostic biomarkers for cutaneous melanoma - Désirée Sexauer
• An engineered lectin, SubB2M, can detect N-glycolylneuraminic acid biomarkers in sera from breast cancer patients - Lucy K Shewell
• Engineering antibodies to trigger BAK-mediated apoptosis in cancer cells - Hema Preethi Subas Satish
• Immunostaging for Melanoma - Elnaz Tavancheh
• Generation and characterisation of a unique cohort of rare gynaecological cancer patient-derived xenograft models - Cassandra Vandenberg
• Lymphovascular invasion and risk of recurrence in papillary thyroid carcinoma - Katy Wagner
• Diagnostic performance of blood based liquid biopsies for screening and early detection of cancers – a narrative review with a systematic approach - William WW Wang
• Loss of mutant TP53 does not impair the sustained proliferation, survival or metastasis of a broad range of cancer cells - Zilu Wang
• Automated radiosynthesis of [⁸⁹Zr]Zr-DFOSq-Durvalumab on the iPHASE MultiSyn module - Christian W Wichmann
• Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis - Raymond Yip
• The role of CDK8/19 in regulating intestinal homeostasis and colorectal cancer - Danxi Zhu
• Methyl-testosterone as a novel therapy and immunosensitizing agent in advanced prostate cancer - Mohammadreza Alizadeh Ghodsi
• Radiosurgery prior to resection: a new technique in the management of brain metastases  - Cristian Udovicich
• Desmoglein-2 expression by multiple myeloma is an independent predictor of poor prognosis - Claudine S Bonder

• Investigating the role of mutant p53 protein in the development, sustained growth and therapy resistance of cancers - Andreas Strasser
• ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against ferroptosis - Luke A Selth
• Insights into how cancers establish a tumour-promoting biomechanical microenvironment - Michael Samuel
• DNA methyltransferases drive gastric cancer growth and present a therapy target for gastric cancer - Anne Huber
• Molecular and functional characterization of melanocyte subpopulations in the epidermis of adult human hairy skin based on single-cell RNA sequencing - Fumihito FN Noguchi
• Unravelling stromal-immune niches in breast cancer using single cell and spatial transcriptomics - Sunny Wu
• Mapping the matrisome of pancreatic tumours using quantitative proteomics - Brooke A Pereira
• Transcriptional and epigenetic profiling of early precursor T cells (TPEX) in T cell exhaustion - David Chisanga
• A high-throughput imaging assay for screening drug synergy with 3D prostate cancer organoids - Nicholas Choo
• Tumour antigen-specific effector memory cytotoxic T lymphocytes (CTL) predict response to immune checkpoint blockade therapy - Nicola Principe
• SUGAR-seq enables simultaneous detection of glycans, epitopes and the transcriptome in single cells - Conor Kearney
• MYCN interacts with SNRPD3 and alters spliceosome activity in neuroblastoma to promote cell viability and proliferation - Alice Salib
• Utilising murine pancreatic cancer organoids to understand epithelial-mesenchymal transition in cancer - Ronnie Ren Jie Low

A reminder that flash talks are also available as E-posters.

10x Genomics Panel Discussion

Single Cell and Spatial Technologies in Cancer Research

Moderator:

Leo Chan, PhD

Science & Technology Advisor Lead, APAC

10x Genomics

Panelists:

A/Prof Alex Swarbrick

Garvan Institute of Medical Research

Cátia Moutinho, PhD

Garvan-Weizmann Centre for Cellular Genomics

Ankur Sharma, PhD

Harry Perkins Institute of Medical Research

Abbey Cutchin

Global Oncology Segment Marketing Manager

10x Genomics

• The co-repressor Runx1t1 is essential for MYCN-driven tumorigenesis - Murray Norris
• Single-cell heterogeneity in apoptotic signalling promotes a targetable form of chemoresistance in neuroblastoma - David R Croucher
• Oncofetal Ecosystem: Embryonic Tale of Tumorigenesis - Ankur Sharma
• Deconstructing Solid Tumour Heterogeneity: The Stromal Matrix Perspective - Thomas R Cox
• Context is everything: Aneuploidy in cancer - Uri Ben-David

• CRISPRi screens identify alternative transcripts that drive gastric cancer - Sefi Rosenbluh
• Epigenetic priming in early development and cancer - Melanie Eckersley-Maslin
• Targeting cytoskeletal dynamics as a therapeutic strategy in cancer - Victoria Sanz-Moreno
• The dark side of neutrophils healing power - Ilaria Malanchi